Fluoxetine Transdermal Cream

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Fluoxetine Transdermal Cream

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About Fluoxetine Transdermal Cream for Dogs & Cats



Fluoxetine is FDA-approved for use in separation anxiety in dogs. In addition to the use of medication, much of the behavior literature stresses the importance of behavior-modification training, owner training and addressing environmental issues as cornerstones of successful therapy.


Fluoxetine is useful to treat some but not all forms of aggression in dogs. It is used for inter-dog aggression in conjunction with behavioral training and neutering of the less-dominant dog. Fluoxetine also is used to treat obsessive-compulsive disorders in dogs. Specific phobias such as fear of storms usually are treated by benzodiazepines because of their episodic nature and the drug’s rapid onset of action. There are instances when combining a SSRI and a benzodiazepine are warranted because of the need for a brief period of increased anxiolytic, such as the first half-hour of separation for a dog with marked separation-anxiety.




Fluoxetine is an SSRI. The originally marketed human drug is called Prozac®. This medication increases the serotonin levels. Serotonin is the neurotransmitter responsible for facilitating social interactions, general awareness, coping mechanism and adaptability.

Indoor cats appear to be susceptible to anxiety disorders due to their lack of social skills and the importance of territorial organization. Manifestations of anxiety in cats may include inappropriate elimination, aggression, obsessive-compulsive behavior, hyperactivity or hypervigilance. Fluoxetine may be helpful for cohabitation anxiety, closed-surrounding anxiety, territory-related anxiety, and other emotional afflictions.


Fluoxetine Cream Directions for Use


The Transdermal Gel/Cream dosage form allows the medicine to be absorbed into the bloodstream through the skin of the animals ear.

  • Rub the prescribed amount of medication into the inside of the animal’s ear where there is the least amount of fur.
  • Rub the gel/cream in well using a protective finger cot.  Wash hands well following application of the medication.
  • There may be a residue remaining on the ear after the gel/cream dries.  If a residue exists, it may be wiped off with a damp cloth or a cotton swab.
  • The preparation may be stored at room temperature for up to 3 months.


Fluoxetine Side Effects in Cats


Anorexia and behavior changes (anxiety, irritability, hyperactivity/insomnia and elimination behavior) are the most-commonly reported side-effects in cats. Anorexia is a common enough side-effect in the cat that the client should monitor the cat’s appetite and weight. Dermatitis may occur at the site of transdermal application.


Fluoxetine Side Effects in Dogs


Sedation and anorexia are the most-commonly reported side-effects. Other side-effects include GI upset and behavior changes (anxiety, irritability, hyperactivity and insomnia). Aggression (very uncommon) and seizures also have been reported.


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Fluoxetine Cream for Dogs & Cats

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If you fall outside our local delivery range, as an official US Postal Substation, we can also easily ship your medications to you. We ship most medications for free, and also offer expedited shipping if you need. As we grow, we also serve patients and prescribers in multiple states.



pharmacy registered in multiple statesThe growing list of states we serve now includes:


  • Florida
  • Wisconsin
  • Washington
  • Arizona
  • and more to come!